George Jung (Johnny Depp) wants to be rich as fast as he can. He starts dealing with marijuana with his girlfriend Barbara (Franka Potente). And so the whole westcoast of California gets its drugs from him. But then Barbara dies and George gets inprisoned because of dealing. In prison he gets to know Diego and because of Diego he gets to know the colombian Medellin-Cartel and the drug-king Pablo Escobar. George starts to be part of the real big drug-business: cocaine. Nearly every gram that's in the USA comes from him. When he mets his big love (Pen?lope Cruz) in Colombia and when his friend Diego betrays him, George wants to stop dealing, but he has to learn that relations like that...can't be quit that easily...
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